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State Laws on NTI Substitution: Varying Requirements Across the US

State Laws on NTI Substitution: Varying Requirements Across the US

3.03.2026

State laws on NTI drug substitution vary widely across the U.S., with 27 states banning or restricting generic swaps for medications like warfarin and levothyroxine. While the FDA says generics are safe, real-world evidence shows risks-making patient safety a patchwork of state rules.

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