When you reach for naproxen, a nonsteroidal anti-inflammatory drug used for pain, swelling, and fever. Also known as Aleve, it's one of the most bought over-the-counter painkillers in the U.S. But just because it’s easy to get doesn’t mean it’s safe for everyone. Millions take it for headaches, menstrual cramps, or arthritis, but few know how deeply it affects their stomach, heart, and kidneys.
It’s part of a bigger group called NSAIDs, a class of drugs that reduce inflammation and block pain signals. This group includes ibuprofen, aspirin, and celecoxib. But naproxen lasts longer—up to 12 hours—which sounds good until you realize it’s also harder on your gut. Studies show regular use increases the risk of stomach ulcers by 3 to 5 times, even at low doses. And if you’re over 60, have high blood pressure, or take blood thinners, the risks climb even higher.
It doesn’t just hurt your stomach. Long-term use can raise your chance of heart attack or stroke, especially if you already have heart disease. That’s why the FDA added black box warnings to naproxen labels years ago. It also messes with kidney function, especially if you’re dehydrated or taking diuretics. And mixing it with other painkillers? A bad idea. People often grab naproxen and acetaminophen together, thinking they’re safe, but stacking NSAIDs with aspirin or corticosteroids can be dangerous.
Some folks use it for gout flares or tendonitis, and it works well—but only short-term. There’s no benefit to taking it daily for months unless your doctor specifically says so. And if you’ve ever had a bad reaction to aspirin, you’re likely allergic to naproxen too. It’s not just about dosage; it’s about timing, health history, and what else you’re taking.
Below, you’ll find real posts from people who’ve dealt with naproxen’s side effects, its interactions with other drugs, and how it compares to safer options. Some stories are about unexpected bleeding. Others are about how it helped with chronic pain but wrecked their digestion. There’s no fluff here—just facts from patients and doctors who’ve seen what happens when this common pill goes wrong.
Combining blood thinners with NSAIDs like ibuprofen or naproxen dramatically increases the risk of dangerous bleeding - even from over-the-counter painkillers. Learn why this combo is life-threatening and what to take instead.
