Details
Letro is an aromatase inhibitor (AI) and what this means is it stops the expression of the aromatase enzyme, thus leading to a decline in estrogen levels in the body. Aromatase is responsible for the conversion to some hormones likes estrogen, from other hormones. When for example a test subject has abnormally high testosterone levels this may lead to a raised conversion of testosterone to estrogen via aromatase and give rise to unwanted estrogenic effects. Letro is useful in the research of androgens, estrogens and how they work in the body. Letro has opened doors to not only to possible treatments for cancer (why it was originally developed), but has also been shown effective at promoting spermatogenesis, delay the fusing of the growth plates, Endometriosis and for many other hormonal disorders as well. A common condition seen with abnormally high estrogen levels in males is a condition called Gynecomastia (Gyno) which is the development of female like breast tissue. This can happen even after puberty and Letro has been shown to be very effective at lowering estrogen levels in many research studies, in fact as high at 90% + suppression. This is why Letro is a top pick for researches looking to research the possible treatment of conditions in their research subjects that are related to high estrogen, like for example gyno, edema (bloat) and high blood pressure. REF 1) Suppression of plasma estrogen levels by Letrozole and anastrozole is related to body mass index in patients with breast cancer.Folkerd EJ, Dixon JM, Renshaw L, A'hern RP, Dowsett M. http://www.ncbi.nlm.nih.gov/pubmed/22802308 2) Pharmacogenomics of third-generation aromatase inhibitors.Turkistani A, Marsh S. http://www.ncbi.nlm.nih.gov/pubmed/22594760 3) Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.Gupta A, Mehta R, Alimirah F, Peng X, Murillo G, Wiehle R, Mehta RG. http://www.ncbi.nlm.nih.gov/pubmed/22876562 4) Marked increase of final height by long-term aromatase inhibition in a boy with idiopathic short stature.Krebs A, Moske-Eick O, Doerfer J, Roemer-Pergher C, van der Werf-Grohmann N, Schwab KO. http://www.ncbi.nlm.nih.gov/pubmed/22876562 5) Letrozole versus clomiphene citrate for superovulation in Egyptian women with unexplained infertility: a randomized controlled trial.Ibrahim MI, Moustafa RA, Abdel-Azeem AA. http://www.ncbi.nlm.nih.gov/pubmed/22829102 6) History of aromatase: saga of an important biological mediator and therapeutic target.Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A. http://www.ncbi.nlm.nih.gov/pubmed/19389994 7) Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice.Luthra R, Kirma N, Jones J, Tekmal RR. http://www.ncbi.nlm.nih.gov/pubmed/14623545
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