Welcome to CEMproducts!
This is an amazing compound. It has been referred to as “exercise in a bottle”, and for good reason. It activates 2 main pathways that exert their effects on research subject’s bodies. The same pathways activated when the subjects actually exercise.
The first pathway is the peroxisome proliferator-activated receptor. The PPAR is present largely in adipose tissue (fat). They regulate the gene expressions that control metabolism, specifically the differentiation between carbohydrate , protein and lipid metabolism. What does that mean? Well in layman’s terms it means they control what is burned for fuel and when activated that shifts the preference to adipose (body fat) tissue.
The second pathway is known as AMP-activated protein kinase. AMPk is an enzyme that plays a key role in cellular energy expenditure. It is expressed greatly in skeletal muscle. It regulates fatty acid metabolism, inhibits cholesterol uptake, and promotes glucose uptake to muscle cells. It also plays a role in the regulation of the secretion of insulin.
The combined effect of these 2 pathways is identical to the effects one would observe in a research subject that was observed performing strenuous exercise. The shifting of burning fat for fuel in lieu of carbohydrates, the glucose uptake to muscle cells, the regulation of insulin. All factors combining to burn significant body fat and promote skeletal muscle growth.
This truly is an amazing compound which we are proud to be at the forefront in offering it to you for your research needs. We are confident this will become a substance in huge demand in our research circles.
Refs:
*Berger J, Moller DE (2002). "The mechanisms of action of PPARs". Annu. Rev. Med. 53: 409–35. doi:10.1146/annurev.med.53.082901.104018. PMID 11818483
*Issemann I, Green S (1990). "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators". Nature 347 (6294): 645–50. doi:10.1038/347645a0. 2129546
*Stoppani J, Hildebrandt AL, Sakamoto K, Cameron-Smith D, Goodyear LJ, Neufer PD (December 2002). "AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 283 (6): E1239–. PMID 12388122
*Henin N, Vincent MF, Gruber HE, Van den Berghe G (April 1995). "Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase". FASEB J. 9 (7): 541–6. PMID 7737463
* Uwe Dressel, Tamara L. Allen, Jyotsna B. Pippal, Paul R. Rohde, Patrick Lau, and George E. O. Musc (2003). "The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells". Molecular Endocrinology (17): 2477–93. doi:10.1210/me.2003-015. PMID 14525954
The first pathway is the peroxisome proliferator-activated receptor. The PPAR is present largely in adipose tissue (fat). They regulate the gene expressions that control metabolism, specifically the differentiation between carbohydrate , protein and lipid metabolism. What does that mean? Well in layman’s terms it means they control what is burned for fuel and when activated that shifts the preference to adipose (body fat) tissue.
The second pathway is known as AMP-activated protein kinase. AMPk is an enzyme that plays a key role in cellular energy expenditure. It is expressed greatly in skeletal muscle. It regulates fatty acid metabolism, inhibits cholesterol uptake, and promotes glucose uptake to muscle cells. It also plays a role in the regulation of the secretion of insulin.
The combined effect of these 2 pathways is identical to the effects one would observe in a research subject that was observed performing strenuous exercise. The shifting of burning fat for fuel in lieu of carbohydrates, the glucose uptake to muscle cells, the regulation of insulin. All factors combining to burn significant body fat and promote skeletal muscle growth.
This truly is an amazing compound which we are proud to be at the forefront in offering it to you for your research needs. We are confident this will become a substance in huge demand in our research circles.
Refs:
*Berger J, Moller DE (2002). "The mechanisms of action of PPARs". Annu. Rev. Med. 53: 409–35. doi:10.1146/annurev.med.53.082901.104018. PMID 11818483
*Issemann I, Green S (1990). "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators". Nature 347 (6294): 645–50. doi:10.1038/347645a0. 2129546
*Stoppani J, Hildebrandt AL, Sakamoto K, Cameron-Smith D, Goodyear LJ, Neufer PD (December 2002). "AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 283 (6): E1239–. PMID 12388122
*Henin N, Vincent MF, Gruber HE, Van den Berghe G (April 1995). "Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase". FASEB J. 9 (7): 541–6. PMID 7737463
* Uwe Dressel, Tamara L. Allen, Jyotsna B. Pippal, Paul R. Rohde, Patrick Lau, and George E. O. Musc (2003). "The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells". Molecular Endocrinology (17): 2477–93. doi:10.1210/me.2003-015. PMID 14525954
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