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Dihydrotestosterone (DHT), a steroid hormone produced from testosterone by the enzyme 5-reductase is the primary active metabolite of testosterone In later life, DHT is associated with androgenic alopecia. Users of testosterone based anabolic agents are often at risk of developing disorders associated with excess DHT. These include BPH, scalp hair loss, and acne. Several studies have demonstrated the efficacy and safety of dutasteride.
Type I 5 alpha reductase (AR) is found primarily in the skin and scalp, while the type II enzyme is more localized to the prostate. Since DHT has been implicated in both male pattern baldness and acne in both sexes, we would expect dutasteride to be superior to finasteride in treating these conditions. In one in vitro study (24), Dutasteride completely abolished DHT formation in the skin and scalp. The authors concluded that �Dutasteride may be useful in acne and androgenetic alopecia.�
Independant research on the efficacy of dutasteride for treating hair loss: After six month of treatment, the hair counts measured in a 1 inch diameter circle increased by an average 96 hairs with 0.5mg Dutasteride daily, compared to an average 72 hairs with 5mg Finasteride (Finasteride) daily. So these initial trials show that Dutasteride is around 30% more effective than Finasteride in promoting hair regrowth.
Will dutasteride help hair re-growth for all men?
As with Finasteride, Dutasteride increases the number of scalp hairs, helping to fill-in thin areas of the scalp. Although results will vary, generally men will not re-grow all of the hair they have lost. Male pattern hair loss occurs gradually over time, but Dutasteride can significantly reduce or delay hair loss.
Little research has been carried out on the use of dutasteride for acne treatment. However, Since most experts agree that DHT is involved in acne development and dutasteride blocks the type 1 apha reductase found in skin, one might expect dutasteride to help prevent and treat acne. There are numerous anecdotal accounts of this happening. Interestingly, dutasteride�s competitor finasteride can actually cause acne. This is due to the increase in testosterone associated with finasteride use (as with dutasteride as well). However, since finasteride fails to prevent the conversion of T to DHT in the skin (unlike dutasteride), the higher T levels corrrespond to increased DHT production in the skin.
In summary, then, there is considerable evidence that dutasteride is an effective treatment for BPH. Company sponsored research clearly suggests that dutasteride is superior to finasteride for hair restoration. Regarding acne, we are forced to rely on the extremely positive feedback from dutasteride users.
Type I 5 alpha reductase (AR) is found primarily in the skin and scalp, while the type II enzyme is more localized to the prostate. Since DHT has been implicated in both male pattern baldness and acne in both sexes, we would expect dutasteride to be superior to finasteride in treating these conditions. In one in vitro study (24), Dutasteride completely abolished DHT formation in the skin and scalp. The authors concluded that �Dutasteride may be useful in acne and androgenetic alopecia.�
Independant research on the efficacy of dutasteride for treating hair loss: After six month of treatment, the hair counts measured in a 1 inch diameter circle increased by an average 96 hairs with 0.5mg Dutasteride daily, compared to an average 72 hairs with 5mg Finasteride (Finasteride) daily. So these initial trials show that Dutasteride is around 30% more effective than Finasteride in promoting hair regrowth.
Will dutasteride help hair re-growth for all men?
As with Finasteride, Dutasteride increases the number of scalp hairs, helping to fill-in thin areas of the scalp. Although results will vary, generally men will not re-grow all of the hair they have lost. Male pattern hair loss occurs gradually over time, but Dutasteride can significantly reduce or delay hair loss.
Little research has been carried out on the use of dutasteride for acne treatment. However, Since most experts agree that DHT is involved in acne development and dutasteride blocks the type 1 apha reductase found in skin, one might expect dutasteride to help prevent and treat acne. There are numerous anecdotal accounts of this happening. Interestingly, dutasteride�s competitor finasteride can actually cause acne. This is due to the increase in testosterone associated with finasteride use (as with dutasteride as well). However, since finasteride fails to prevent the conversion of T to DHT in the skin (unlike dutasteride), the higher T levels corrrespond to increased DHT production in the skin.
In summary, then, there is considerable evidence that dutasteride is an effective treatment for BPH. Company sponsored research clearly suggests that dutasteride is superior to finasteride for hair restoration. Regarding acne, we are forced to rely on the extremely positive feedback from dutasteride users.
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